MD SIMULATION STUDIES TO INVESTIGATE ISO-ENERGETIC CONFORMATIONAL BEHAVIOUR OF MODIFIED NUCLEOSIDES M2G AND M22G PRESENT IN tRNA
Modified nucleic acid bases are most commonly found in tRNA.These may contain modifications from simple methylation to addition of bulky groups.Methylation of the four canonical nucleotide bases at a wide variety of positions is particularly prominent among the known modification.Methylation of N2 group of guanine is a relatively common modificatio